P2X7Rs: new therapeutic targets for osteoporosis

[摘要] Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with infammation,especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bonemetabolism. Numerous evidence suggested that purinoceptor networks are essential for bone homeostasis. In this review, therelationship between infammation and the development of osteoporosis and the role of P2X7 receptor (P2X7R) in regulatingthe dynamic regulation of bone reconstruction were covered. We also discussed how P2X7R regulates the balance betweenresorption and bone formation by osteoblasts and reviewed the relevance of P2X7R polymorphisms in skeletal physiology.Finally, we analyzed potential targets of P2X7R for osteoporosis.

[学科分类] 分子生物学，细胞生物学和基因

[关键词] Inflammation;Osteoporosis;P2X7 receptor;Osteoclasts;Osteoblasts