Burnstock oration — purinergic signalling in kidney transplantation

[摘要] Kidney transplantation is the preferred treatment for individuals with kidney failure ofering improved quality and quantityof life. Despite signifcant advancements in short term graft survival, longer term survival rates have not improved greatlymediated in large by chronic antibody mediated rejection. Strategies to reduce the donor kidney antigenic load may translateto improved transplant survival. CD39 on the vascular endothelium and on circulating cells, in particular regulatory T cells(Treg), is upregulated in response to hypoxic stimuli and plays a critical role in regulating the immune response removingproinfammatory ATP and generating anti-infammatory adenosine. Herein, the role of CD39 in reducing ischaemia–reperfusion injury (IRI) and on Treg within the context of kidney transplantation is reviewed.

[学科分类] 分子生物学，细胞生物学和基因

[关键词] CD39;ATP;Adenosine receptors;Regulatory T cells;Treg;Ischaemia reperfusion injury