Modeling the microenvironment special issue

[摘要] Studying the complexity of human physiology and pathology requires the utilization of efective in vitro and in vivomodels. This year marks the 40th anniversary since thediscovery of one of these models, Matrigel (Grant et al.,1989; Kleinman et al. 1992; Passaniti et al. 2021). This editorial introduces a very special issue of Journal of Cell Communication and Signaling which has two purposes: one is tocommemorate this anniversary; the other is to acknowledgethe essential contributions of George Martin to not only thisdiscovery, but also his overall contribution to extracellularmatrix biology. When in charge of the science at FibroGen,George recruited not only myself, but also individuals essential for the early successes of FibroGen, including: MarkdiNicholo and Patti Segarini. These people were principallyresponsible for the science that resulted in the establishment of FibroGen’s frst two partnerships, with Taisho andSankyo. George also raised global interest in CCN proteinsby creating key relationships with academia.

[学科分类] 分子生物学，细胞生物学和基因