Anti-inflammatory, Anti-oxidative and Anti-bacterial Activities of the Constituents Extracted from Leaves of Talipariti hamabo

[摘要] Talipariti hamabo is a plant growing around salt marshes in the Lava Coast region of Jeju Island, Korea. In thisstudy, the extract of T. hamabo leaves was investigated for the anti-inflammatory, anti-oxidative and anti-bacterial activitiesand their active constituents were identified. In the anti-inflammatory tests using lipopolysaccharide-stimulated RAW264.7cells, the ethyl acetate (EtOAc) fraction inhibited the nitric oxide production without causing cell toxicity. Moreover, theEtOAc fraction reduced pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-6) as well as prostaglandin E2. In theanti-oxidative studies with DPPH and ABTS+ radicals, potent scavenging activities were observed in the EtOAc and n-butanolfractions. Upon the anti-bacterial tests using Staphylococcus epidermidis, EtOAc and n-butanol fractions exhibited good activities.Through the phytochemical studies on EtOAc fraction, three components were isolated by repeated column chromatography;oleic acid (1), p-hydroxyphenethyl-trans-ferulate (2), nicotiflorine (3). Based on these results, the extract of T. hamabo leavescan be developed as natural resources for cosmetic applications.

[学科分类] 化学（综合）

[关键词] Talipariti hamabo;Anti-inflammation;Anti-oxidation;Anti-bacterial;Isolation