Perspective of Next Generation Risk Assessment (NGRA) using New Approach Methodologies (NAMs) : Review on Accelerating the Pace of Chemical Risk Assessment (APCRA) Initiative
[摘要] During the past few decades, toxicity science is shifting from observative to predictive science. New approachmethodologies (NAMs), including in chemico, in silico, in vitro approach, gain attention to reduce, refine, replace the wholeanimal toxicity testing. However, actual acceptances of NAMs in regulatory decision-making have been limited due to lowconfidence. To address the current constraints, Accelerating the Pace of Chemical Risk Assessment (APCRA) initiative conducted several case studies and presented the perspectives of next generation risk assessment (NGRA). In this review, we suggested a concept and perspectives of NGRA through analysis on APCRA case studies.
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[效力级别] [学科分类] 化学（综合）
[关键词] New Approach Methodologies (NAMs);Accelerate the Pace of Chemical Risk Assessment (APCRA);Next Generation Risk Assessment (NGRA);Chemical management [时效性]
