Study of Glycyrrhizic Acid:menthol Supramolecular Complexes on Mitochondrial Functional Activity in in-vitro Experiments

[摘要] Here we present how a supramolecular complex of Glycyrrhizic acid (GA) with Menthol (Mt) affects the bloodglucose levels and glycogen synthesis in the liver of rats in in-vivo experiments with diabetes caused by alloxan. We haveshown that Menthol, Glycyrrhizic acid and GA:Mt supramolecular complexes can restore functional dysfunction of the livermitochondria in alloxan diabetes, i.e., inhibit lipid peroxidation. The hypoglycemic activity and mitochondrial membrane stabilizing properties of the supramolecular complex GA:Mt (4:1) in alloxan diabetes were more pronounced than those of menthol, GA and its GA:Mt (2:1) and GA: Mt (9:1) supramolecular complexes.

[学科分类] 化学（综合）

[关键词] Menthol;Glycyrrhizic acid;Homeostasis;Aloxan diabetes;Glycogen;Lipid peroxidation;Supramolecular complex