A descriptive study of histopathological features of breast carcinoma: a single centre experience

[摘要] Introduction and objectives: Muscle biopsies are valuable in evaluating muscle disorders. TheDepartment of Pathology, Faculty of Medicine, Peradeniya is the only centre in the country whichperforms enzyme assays and immunohistochemistry in muscle biopsies. This study aims to determinethe prevalence of diseases diagnosed in muscle biopsies.Method: This is a retrospective study carried out using muscle biopsies received from 2009 to 2020.Clinicopathological data and diagnoses were extracted from the archives, recorded and analysed usingMS Excel software. Patients under 18 years were categorized under the paediatric group.Results: 593 muscle biopsies have been reported during the study period. There were 364 paediatricbiopsies, out of which 38% (n=137) were muscular dystrophies. Out of muscular dystrophies, 29%(n=40) were diagnosed as Duchenne muscular dystrophy and 11.7% (n=16) as Becker musculardystrophy. 19% (n=70) of paediatric biopsies showed a congenital myopathy. Out of 229 adultbiopsies, 26% (n=59) were diagnosed as muscular dystrophy, 31.4% (n=72) as inflammatorymyopathies and 10.5% (n=24) were non-specific myopathies.Discussion and conclusion: Worldwide prevalence rates of muscle diseases vary with age, locationand study population. Duchenne muscular dystrophy is the commonest muscular disease amongchildren which is the same in our study, and adult prevalence rates are variable among differentstudies. No studies on prevalence rates among Sri Lankans have been carried out to date, highlightingthe need for prevalence studies on muscle diseases in Sri Lanka.

[学科分类] 生理学与病理学