Correlation of Body Composition and Quality of Life in Maintenance Hemodialysis Patients

[摘要] Background: Due to the occurrence of hemodialysis, the life expectancy of end-stage renal disease (ESRD) patients is lengthening. However, their quality of life (QoL) is decreasing. The QoL of ESRD patients is composed of physical component score (PCS), mental component score (MCS), and kidney-related component score (KDCS) components. Nutritional status is one of the influencing factors of QoL. It is unclear whether free fat mass (FFM) or fat mass contributes to the increase of QoL in ESRD patients. Objectives: This study aimed to identify the correlation between FFM percentage and the QoL of ESRD patients. Methods: This cross-sectional study was conducted in Hemodialysis Unit, Division of Kidney and Hypertension, Dr. Cipto Mangunkusumo General Hospital, Jakarta from June to July 2018. In this study, 102 subjects were included. Blood samples were collected for laboratory examination. FFM percentage was measured using bioimpedance analysis (BIA). Meanwhile, QoL was evaluated using KDQOL SF-36 version 1.3. Statistical analysis was done using Pearson correlation test. Analysis of QoL was done based on fat percentage using ANOVA test. Results: In this study, the overall KDQOL score was 47.86 ± 6.56 with PCS 40.97 ± 9.66, MCS 46.6 (22.05 - 59.95), and KDCS 55.98 ± 9.02. FFM percentage was 74.21 ± 1% with mean mass of 43.06 ± 8.16 kg. Statistical analysis showed no correlation between FFM percentage and overall KDQOL score (r 0.032, P 0.750). However, there was a significant correlation between PCS and FFM (r 0.223, P 0.024). Conclusions: There is a weak positive correlation between FFM in kg and the physical quality of end-stage kidney disease (ESKD) patients.

[学科分类] 基础医学

[关键词] Free Fat Mass Percentage (FFM);Bioimpedance Analysis (BIA);Quality of Life;KDQOL SF-36;End-Stage Renal Disease (ESRD)