Genome-wide association studies for thyroid physiology and diseases

[摘要] Genetic factors are involved in the etiology of most diseases, but prior to 2000, the methods for identifying such factors were very limited. Genome-wide association study (GWAS), developed in the 2000s, is an analytical method that can be applied to most diseases, including endocrine disorders. GWAS has provided a wealth of information on disease risks and the molecular pathogenesis of many human diseases. This review summarizes key findings from GWAS for thyroid physiology and diseases, and illustrates how GWAS is a powerful research tool to elucidate the molecular mechanisms of the diseases.

[学科分类] 内分泌与代谢学

[关键词] Genome-wide association study;Genetics;Thyroid cancer;Thyroid function test;Thyroid dysgenesis