Small Round Cells in Sinonasal Tract: Pathologists Approach for the "Blues"

[摘要] The sinonasal cavities host a wide variety of undifferentiated malignancies with round cell morphology. The differential diagnosis is difficult for a practicing surgical pathologist, especially on very small sample, sometimes with artifactual changes. The correct classification is clinically relevant as it has implications on the management. Further, newer entities are added as we expand our understanding in these tumors. The aim of this review is to provide a comprehensive review of the variety of tumors we encounter, try for a broader classification based on histological hints as well as with an initial panel of immunohistochemistry. The further classification as individual entities is also described with their characterizing features, with a special reference to the ancillary testing to give a more objective picture. Overall, prognosis and general approach for managing the specific entity are also addressed in a nutshell.

[学科分类] 皮肤病学

[关键词] Esthesioneuroblastoma;head-and-neck cancers;sinonasal tumors;small round cell neoplasms