Cypermethrin-Induced Alterations in Serum Calcium and Phosphate of Rats: Protective Role of Jamun Seed and Orange Peel Extracts

[摘要] The present study investigated alterations in serum calcium and phosphate levels induced by cypermethrin (trade name Basathrin) exposure to rats and aimed to evaluate protecting role of jamun (Syzygium cumini) seed (JSE) and orange (Citrus sinensis) peel (OPE) extracts. Wistar rats were treated as - Group A: Control; Group B: cypermethrin (CY); Group C: cypermethrin and jamun seed extract (CY+JSE); Group D: cypermethrin and orange peel extract (CY+OPE); Group E: orange peel extract (OPE); Group F: jamun seed extract (JSE). Cypermethrin dose was 25 mg/ kg body wt/day whereas orange peel and jamun seed extract dose was 200 mg/kg body wt/day. Serum calcium and phosphate were analyzed after 15 days and 30 days following the treatment. Serum calcium of rat treated with cypermethrin decreased after 15 and 30 days. In-group C, serum calcium decreased on day 15 and 30. In-group D serum calcium decreased at day 15 but on day 30 level increased. Calcium levels in-group C increased on day 15 and 30 as compared to group B. Moreover, levels in-group D is not significant on day 15 and 30. In cypermethrin exposed rats, serum phosphate declined from day 15 to 30. In-group C, serum phosphate decreased at day15, which continued till day 30. Serum phosphate in-group D treated rats decreased on day 15 and 30. In groups E and F, there is no change in serum phosphate of rats on day 15; however, on day 30 levels decreased. It can be concluded that cypermethrin treatment (25 mg/ kg body wt/day) caused alterations in the serum calcium and phosphate of the rats. The changes in these electrolytes could be protected by supplementation of extracts of jamun seed and orange peel at 200 mg/kg body wt/day. It is suggested that the cypermethrin exposed organisms should be given dietary supplement of these botanical extracts, which would reverse the toxic symptoms.

[学科分类] 生物科学（综合）

[关键词] Cyprmethrin;Serum calcium;Serum phosphate;Jamun seed;Orange peel