Oxidative Toxic Stress and DNA Damage as a Promising Strategy for Identifying Patients with Nonalcoholic Fatty Liver Disease

[摘要] Non-alcoholic fatty liver disease (NAFLD) is considered as one of the common causes of chronic hepatitis and cirrhosis. The present study was performed to determine paraoxonase 1 (PON 1) and arylesterase (ARE) activities, biomarkers of oxidative toxic stress and DNA damage in patients with NAFLD and their suitability for identifying for NAFLD. In this case-control study, 40 NAFLD patients and 40 normal subjects were studied. Abdominal ultrasonography, serum PON 1 and ARE activities, level of lipid peroxidation (LPO), total thiol groups (TTG), total antioxidant capacity (TAC) and DNA damage biomarker were measured in both NAFLD patients and control group. There was a significant increase in salt stimulated PON 1 activity and LPO level in NAFLD patients compared to the control group (P0.05). PON 1 activity and LPO level can be considered as biomarkers for NAFLD diagnosis. Along with these biomarkers, total antioxidant capacity can be used for identifying patients with NAFLD.

[学科分类] 生物科学（综合）

[关键词] paraoxonase 1;oxidative stress;DNA damage;nonalcoholic fatty liver disease (NAFLD)