An Immunological Argument for One Health

[摘要] Human exposure to heavy metals is associated with higher ratesof immunological deficiencies, autoimmunity, and cancer. Chronicexposure to lead contributes to abnormalities in immunomodulationwhile cadmium is linked to breast, prostate, and lung cancers. Prenatalexposure to these metals impacts both the development and function ofimmune cells. The concept of one health underscores the importance ofthe interface between human, animal, and environmental health. Herein,we highlight heavy metal exposure via honey consumption as an exampleof the critical intersection of these factors as they relate to immunologicalimpacts and downstream pathologies.

[学科分类] 过敏症与临床免疫学

[关键词] Heavy Metals;Lead;Cadmium;Autoimmunity;Tumorigenesis