The The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study

[摘要] Introduction: Multiple sclerosis (MS) is an autoimmune disease. Inflammatory cells, cytokines, and chemokines play a major role in the pathogenesis of the disease. Low-level laser therapy (LLLT) as a photobiostimulation approach could affect a wide range of cellular responses. LLLT inhibits the inflammatory signaling pathway, improves cell viability, inhibits apoptosis, modulates immune responses, and induces the production of growth factors.Methods: In this review, we discuss the effect of LLLT on cellular responses and its application in the treatment of MS. Such keywords as “low-level laser therapy”, “photobiomodulation” and “multiple sclerosis” were used to find studies related to laser therapy in MS in Google scholar, PubMed, and Medline databases.Results: LLLT reduced the inflammatory immune cells and mediators. It also enhanced the regeneration of neurons.Conclusion: Investigations showed that besides current treatment strategies, LLLT could be a promising therapeutic approach for the treatment of MS.

[学科分类] 基础医学

[关键词] Low-level laser therapy (LLLT);Multiple sclerosis (MS);Photobiomodulation;Laser therapy;Autoimmune disease