Keloid Treatment Using Plasma Exeresis: A Pilot Trial Study

[摘要] Introduction: Keloid scars and hypertrophic scars are more commonly seen after surgeries, sutureplacements, or other skin damages. Scars can be treated using a variety of methods, includingtopical compounds, surgery, and lasers. The aim of this study is to evaluate the effects of plasmaexeresis on the treatment of keloid scars.Methods: This experimental study was conducted on patients with keloid scars, defined as atreatment-resistant subtype of scars with extension beyond the primary skin defect and cauliflowerappearance, in different parts of the body. The patients were treated with 2-to-3-session plasmaexeresis. Scars were examined based on the Vancouver scar scale (VSS) before and 5 months afterthe treatment.Results: A total number of 24 scars were enrolled in this study. The number of patients was 16.There was a decrease in the mean thickness of keloids from 2.20 to 0.54 (P=0.000). The meanpigmentation and pliability scores decreased from 1.54 and 2.16 to 0.375 and 0.541, respectively(P=0.001). There was a significant reduction in the keloid scar vascularity score from 1.666 to0.541 (P=0.000). There was a decrease from 0.708 to 0.00 (P=0.004) in the mean itchiness score.After the intervention, the mean pain score was 0.000, compared to 0.7500 before the intervention(P=0.003). There was a decrease in the total score from 8.958 to 2.000 (P=0.000).Conclusion: The plasma exeresis procedure is effective in destroying small keloid scars. Furthermore,results in less itching and pain, as well as no significant complications or recurrences.

[学科分类] 基础医学

[关键词] Keloid scar;Keloid treatment;Plasma exeresis;Plexr;Skin surgery