Therapeutic Effects of Photobiomodulation Therapy on Multiple Sclerosis by Regulating the Inflammatory Process and Controlling Immune Cell Activity: A Novel Promising Treatment Target

[摘要] Introduction: Multiple sclerosis (MS) is one of the autoimmune and chronic diseases of the central ‎nervous system, this disease occurs more frequently in young people and women ‎and leads to neurological symptoms. Oxidative stress, inflammatory process, and ‎oligodendrocyte dysfunction has a pivotal role in the pathophysiology of this ‎disease. Nowadays, it has been reported that Photobiomodulation (PBM) as a non-invasive threat has neuroprotective potential but the exact mechanisms are not understood.   Methods: In this manuscript, we have reviewed the Photobiomodulation effects on MS. in this regard, we used "Photobiomodulation", " Laser therapy", and "Low-level laser therapy" keywords on MS to find related studies on this subject in PubMed, Google scholar, Elsevier, Medline, and Scopus databases.  Results: Photobiomodulation has positive effects on MS by regulating the inflammatory ‎process, controlling immune cell activity, and mitochondrial functions, as well as inhibiting free ‎radicals’ production. ‎ Conclusion: Overall, researchers have suggested that laser therapy could be considered a promising new treatment for neurodegenerative diseases, such as multiple sclerosis.

[学科分类] 基础医学

[关键词] Multiple sclerosis;Photobiomodulation;Low-level laser therapy