Photobiomodulation Therapy and Cell TherapyImproved Parkinson’s Diseases by Neuro-regenerationand Tremor Inhibition

[摘要] Introduction: Parkinson's disease is a progressive and severe neurodegenerative disorder of the central nervous system. The most prominent features of this disease are cell reduction in Substantia nigra and accumulation of α-Synuclein, especially in the brainstem, spinal cord, and cortical areas. In addition to drug-based treatment, other therapies such as surgery, cell therapy, laser therapy can be mentioned. In this study, articles on cell therapy and laser therapy for Parkinson's disease have been collected to evaluate the improvement of motor function, cell differentiation, and dopaminergic cell proliferation. Method: Articles were collected from four electronic databases PubMed, Scopus, Google Scholar Web of Science from 2010 to 2022 and electronically to study the effects of stem cell therapy and laser therapy on Parkinson's disease through the keywords "photobiomodulation", "low-level light therapy", "Low-level laser therapy", "near-infrared light", "Parkinson's disease", "Parkinsonism" and "stem cell therapy" were searched. About 80 related articles were included in the study. Result: The results of studies show that cell therapy and laser therapy are each useful in the treatment of Parkinson's disease and despite their limitations can be useful in improving Parkinson's disease. Conclusion: Concomitant use of cell therapy and Photobiomodulation therapy can improve the symptoms of Parkinson's.

[学科分类] 基础医学

[关键词] Parkinson's disease;near-infrared light;laser therapy;stem cell therapy