Evaluation of Efficacy and Safety of Low-Fluence Q-Switched 1064-nm Laser in Infra-orbital Hyperpigmentation Based on Biometric Parameters

[摘要] Introduction: Dark circles and wrinkles under the eyes are common cosmetic problems, caused byvarious conditions, especially aging and overproduction of melanin in the epidermis or dermis of theskin. Iin addition to the application of topical lightening agents, different types of lasers, especiallythe Q-Switched ND:YAG laser, have been used for the treatment of cutaneous hyperpigmentation.Because of a high prevalence of idiopathic eye dark circles (EDCs) or periorbital melanosis and apoor response to available therapies, we decided to evaluate the efficacy and safety of the FractionalQS 1064 nm ND:YAG Laser through a before-after trial.Methods: 18-65-year-old patients with skin Fitzpatrick phototype of I-V and without any usage of atopical or systemic therapeutic regimen (2-4 weeks before the trial) were enrolled in the study. Eachpatient was treated with 6 sessions of the Fractional QS 1064 nm ND:YAG Laser at 2-week intervalsand assessed for response and possible side effects or recurrences through 4 outcome measures,including Visoface-based color and erythema, melanin index and lightness (Before the fourth andsixth sessions of the therapy; also 1 week and 3 months after finishing the trial).Results: The changes of Visoface-based color and erythema, the melanin pigment amount by theMexameter (melanin index) and the degree of lightness by the Colorimeter of patients after 6 monthsof intervention were statistically significant (P<0.001).Conclusion: The fractional QS 1,064 nm ND:YAG Laser is an effective and safe therapy in EDCssince objective outcomes like the reduction of the melanin index and improving lightness andsubjective ones like the reduction of darkness and erythema were confirmed.

[学科分类] 基础医学

[关键词] Eyelids dark circle;Periorbital hypermelanosis;Q-switched 1064-nm laser;Hyperpigmentation;Hypermelanosis