Evaluation of C4b as an adjunct marker in symptomatic RT-PCR negative Covid-19 cases

[摘要] Introduction Detecting low viral load has been a challenge in this pandemic, which has led to its escalated transmission. Complement activation has been implicated in pathogenesis of Covid-19 infection. Thus, evaluation of complement activation in suspected Covid-19 infection may help to detect infection and limit false negative cases thus limiting transmission of infection. We speculate that measuring C4b, produced from an activated complement system due to the presence of Covid-19 may help in its detection, even when the viral titers are low.

[学科分类] 过敏症与临床免疫学

[关键词] Covid-19;Complement pathway;C4b;RT-PCR