Impact of Covishield Vaccination in Terms of SARS CoV-2 Neutralizing Antibody Expression

[摘要] 10AU/ml). In COVID-19 uninfected subjects, there was a sudden incline in neutralizing antibody after the 2nd dose. Infection with SARS CoV-2 between 1st and 2nd dose of Covishield vaccination implicate that the level of neutralizing antibody in serum after 1st dose was not adequate to combat the virus and prevent infection. We observed COVID-19 infection in participants even after 2nd dose of vaccination. Interestingly, there was no protection against SARS CoV-2 even with a high neutralizing antibody expression of 188.5 AU/mL after the 2nd dose. Findings of Covishield efficacy in different cohort samples before and after 2 doses of Covishield vaccination provide impetus for improvement or development of next generation vaccines.

[学科分类] 过敏症与临床免疫学

[关键词] Neutralizing antibody;Electrochemiluminescence Immunoassay;Covishield;COVID-19;SARS CoV-2