100 Years of Haldane’s Rule

[摘要] J.B.S Haldane, a polymath with extraordinary intellectualqualities, contributed significantly to 20th-century biology,especially to evolutionary theory and genetics. Among hismajor contributions is a generalisation that has come to becalled ‘Haldane’s Rule’. It states that among the offspringborn to parents from two different animal races, if one of thesexes is absent, rare, or sterile, that sex is characterised byunlike sex chromosomes. Haldane’s rule remains an unusualexample of something like a law of nature in biology and thuscontinues to attract attention and debate. We discuss some ofthe more interesting attempts to explain why the rule works.

[学科分类] 社会科学、人文和艺术（综合）

[关键词] J.B.S Haldane;sterility;inviability;Dobzhansky–Muller model;faster male hypothesis.