Inhaled antibiotics and airway bacterial decolonization for patients with chronic obstructive pulmonary disease: The rationale and future

[摘要] According to the Global Burden ofDisease (GBD) study, chronic obstructivepulmonary disease (COPD) has becomethe third leading cause of death all over theworld. The high prevalence, years lived withdisability (YLDs), and disability-adjustedlife-years (DALYs) of COPD make ita significant challenge for health-caresystem.[1] More importantly, it has beenproved that severe exacerbations of COPDare associated with the worse survivaloutcome and the mortality can even increasewith the frequency of severe exacerbations.[2]Therefore, the prevention of acuteexacerbations of COPD (AECOPD) isurgently needed.