Diagnostic Values Of Serum Cystatin C And Urinary Fetuin-A As Early Biochemical Markers In Predicting Diabetic Nephropathy Among Patients With Type 2 Diabetes Mellitus.

[摘要] Diabetes accounts for 30% to 50% of the incident cases of end-stage kidney disease in the UnitedStates and also in Egypt is the second leading cause of end stage renal disease after hypertension. The currentstudy aimed to determine the validity of urinary fetuin-A and serum cystatin C as early diagnostic biomarkersof diabetic kidney disease in type 2 diabetes mellitus (T2DM). Fifty patients with type 2 diabetes mellitus werecategorized into two subgroups, group I noromoalbuminuric diabetics [with normal albumin/creatinine ratio(A/C ratio)], group II microalbuminuric diabetics (with A/C ratio more than 30 mg Alb/ g creat) compared to 20apparently healthy non diabetic individuals with matched age (group III). Serum cystatin C and urinary Fetuin-A were measured in addition to albumin/ creatinine ratio and creatinine. Estimated glomerular filteration rate(eGFR) has been calculated. Overall, there were significant elevations of both serum cystatin C and urinaryfetuin –A in microalbuminuric diabetic patients than noromoalbuminuric diabetic patients ( p value =0.0001).There were significant positive correlations between serum cystatin C and urinary Fetuin-A in bothnormoalbuminuric and microalbuminuric diabetic patients (p˂0.05 for all). Serum cystatin C at cut-off point>>1.6 mg/ml showed 96% sensitivity , 94% specificity, while for urinary feutin-A (at cut-off point> 120 mg/L)were 98%, 96%respectively, in predicting diabetic nephropathy among T2DM. Both serum cystatin C andurinary Fetuin-A can be used as early biomarkers for diabetic nephropathy in T2DM.

[学科分类] 工程和技术（综合）

[关键词] Cystatin-C;Fetuin-A;biomarkers;Diabetic nephropathy;T2DM.