In-Silico Screening Of Certain Bioactive Compounds From Ceasalpaniabonduc (Fever Nut) For Select Class I And II Type Human Olfactory Receptors (ORs) Against Asthma And COPD

[摘要] Olfactory receptors (OR) belong to trans membrane proteins (GPCRs) and are effective drug targets.The occurrence of class I (sense water-borne odors) and class II type (sense air-borne odors) human ORs notonly depict odor diversity, but also illustrates receptor specificity. Insilico screening showed significant dockingscores for the compounds from Ceasalpania bonduc(Kantkarej in Hindi, Kuberakshi in Sanskrit) andare closeto the commercial drug theophylline, other familiar natural compounds. Further, these findings suggest thepharmacological features, novel compounds of the herb to treat asthma, chronic obstructive pulmonarydisease (COPD), malaria and can be used in aromatherapy, intra nasal drug delivery (INDD) -a painless drugdelivery system.

[学科分类] 工程和技术（综合）

[关键词] In-Silico;Ceasalpania bonduc;human olfactory receptors;COPD.