Synthesis, Characterization And Applications Of Chitosan Linked Nanopolymer Using Jasminum sambac Leaf Extract.

[摘要] Nanotechnology makes an impact in all spheres of human life and creates increasing excitementespecially in the field of biomedicine and bio-nanotechnology. The main synergism between nanotechnologyand green chemistry is the use of bioactive chemicals for the synthesis of nanoparticles. Chitosan is a natural,biocompatible, biodegradable, nontoxic and easily available polymer that can be used to preparenanoparticles. Chitosan nanoparticles can be widely used in pharmaceutical industries as drug deliveryvehicle. The present research was focused on fabrication of biomolecules loaded chitosan nanoparticles usingJasminum sambac leaf extract. The nanopolymer was synthesised using ionic gelation technique and wascharacterized using UV spectrophotometer and FTIR. The optical density of the broad peak of Chitosan-jasmine-1 -1nanopolymer was found at 3.5242. The FTIR results recorded the absorption peaks at 2112 cm , 1636 cm and-13327 cm which represented the C-H stretch, C=C stretch and O-H bond stretching respectively. Thus, therewas a stretching from higher wavelength region to lower wavelength region demonstrating the interaction oftripolyphosphate with chitosan and biomolecules by reduced hydrogen bonding. The present study stronglysuggested that the fabricated phytochemicals cross-linked with chitosan nanoparticles from Jasminum sambacleaf extract exhibited various activities such as enhanced cytoprotective effects and 75% DNA damageinhibition effects. Thus, the results of our study lend pharmacological credence to the bio-medical applicationsand ethno medical use of this plant in traditional system of medicine in the near future.

[学科分类] 工程和技术（综合）

[关键词] Chitosan;Jasminum sambac;Cytoprotection;DNA damage.