Efficient Procedure For Synthesis Of Cefotaxime Sodium Using Sodium-2-Ethylhexanoate As The Source Of Sodium Ion.

[摘要] Cefotaxime sodium is an antibiotic that has high economic value as well as the necessary but expensive.This research aims to find an efficient procedure for the synthesis of cefotaxime sodium. In this research,cefotaxime sodium was synthesized from cefotaxime acid and sodium-2-ethylhexanoate. The optimalconditions for the synthesis were obtained as following: mole cefotaxime acid/mole sodium-2-ethyl hexanoate= 2:3; ethanol food grade as a solvent, reaction time at 10 minutes and room temperature. The yield ofcefotaxime sodium was 97.11% based on cefotaxime acid and the purity was 99.10%. The chemical structureand molecular weight of products were identified with FTIR, NMR, and LC – Mass Spectrometry.The qualityproduct testing is also done with the parameters solubility product in aqueous and acid media, absorbance value,pH in aqueous media, and purity. The products meet the requirements of the United States Pharmacopeia, JapanPharmacopeia, and British Pharmacopeia.

[学科分类] 工程和技术（综合）

[关键词] Cefotaxime sodium;efficient procedure;sodium-2-ethyl hexanoate;Pharmacopeia