Assessment of Serum Copeptin in Relatively Well Controlled and Uncontrolled Children and Adolescents with Type 1 Diabetes Mellitus.

[摘要] Copeptin is co-released with arginine vasopressin from hypothalamus. The role of copeptin inuncontrolled type 1 diabetes mellitus warrants more investigation. To estimate serum Copeptin in relativelywell controlled and uncontrolled children and adolescents with type 1 diabetes mellitus and its relation toclinical, anthropometric parameters and laboratory variables. Also to test if, RS 58542926 variant could affectthe serum copeptin level. The study compromised 36 well Controlled, 35 uncontrolled Typ1 diabetic casesand 48 healthy children's controls. Copeptin levels and Genotyping of RS 58542926 were determined. Casesexhibited significantly higher values of the Diastolic BP, FBG, HbA1C, cholesterol and serum copeptin thancontrols (P=.024, P<.001, P <.001, P= .012 and P < .01 respectively). Statistically significant positive correlationbetween serum copeptin and gender, diastolic BP, HbA1C and cholesterol in diabetic patients was detected (r=.433**, .252*, .255*, .217* respectively) . RS 58542926 genotype and HbA1C were the most independentpredictors of copeptin (P <.001&.003 ) respectively. Serum copeptin was elevated in uncomplicated diabeticchildren. It was not an independent predictor of the uncontrolled cases of Type1Diabetes Mellitus . RS58542926 variant and HbA1C were the most independent predictors of serum copeptin.

[学科分类] 工程和技术（综合）

[关键词] Copeptin;HbA1C;RS 58542926;Type 1 diabetes mellitus.