Outcome Of Neurodevelopment And Bera In Neonatal Hyperbilirubinemia.

[摘要] Neonatal hyperbilirubinemia is a significant burden in the childs development and the effect ofbilirubin neurotoxicity has a greater impact on the neurodevelopment and hearing abnormalities of thegrowing child. This study was conducted to evaluate long term consequences of bilirubin toxicity on bothneurodevelopment and hearing. A total of 34 neonates with bilirubin levels more than 20mg/dl wereenrolled during the period of 3 years in Dr.D.Y.Patil Medical College. Neurodevelopmental assessmentusing TDSC and Hearing assessment using BERA was done on all 34 neonates at birth and at 1 year of ageto see the changes in abnormalities. Out of the 34 neonates 22(64.7%) had abnormal BERA at the time ofdiagnosis with abnormality of wave V(61%), abnormality of wave III(35%) and prolonged interpeaklatency(3%)and all the neonates(34) had normal BERA at followup of 12 months of age (p value<0.0001). Among 34 neonates all the subjects had normal neurodevelopment at the time of diagnosis and12 months of age. Conclusions: Neonates with hyperbilirubinemia (bilirubin levels more than 20mg/dl)should be screened for neurotoxic effect of hyperbilirubinemia causing damage to neurodevelopment andauditory pathway. Early evaluation by BERA and TDSC scale is necessary to prevent permanentneurological and hearing damage.

[学科分类] 工程和技术（综合）

[关键词] Neonatal Hyperbilirubinemia;BERA;Neurodevelopment;bilirubin encephalopathy.