Investigation of Phytochemical, Pharmacological Activities of Daucus Carota Subs P. Sativus Extract on Streptozotocin Induced Diabetic Rats.

[摘要] The present study is to explore the methanolic extracts of leaves of Daucus carota subsp sativusand fractions were studied streptozotocin induced diabetic rats. The dried leaves were powder andextracted with methanol solvent by using hot continuous percolation (soxhelt) method. The alkaloids,carbohydrate, flavonoids, phenolic compounds, and tannins contents of methanolic extract and itsfractions were also determined and correlated with its antidiabetic activity. The methanol extract and itsfractions curtained for streptozotocin induced diabetic rats in this study gilbenclamide as cast-off forstandard. Methanolic extract of Daucus carota subsp sativus revealed that LD >2000mg/kg, the biological50 dose was fixed at methanolic extract Daucus carota subsp sativus 200mg and 400mg of body weight for theextract. The methanolic extract of Daucus carota subsp sativus leaves result that revealed of alkaloids,carbohydrate, flavonoids, phenolic compounds, and tannins. The pharmacological activity of methanolicextract of Daucus carota subsp sativus leaves all values are expressed as statistically significant at a*=(p<0.001) for glucose tolerance and change in blood glucose level.

[学科分类] 工程和技术（综合）

[关键词] Daucus carota subsp sativus;Solvent extraction;Streptozotocin and Glibenclamide;Oral glucose tolerance and In-vivo Anti-diabetic studies.