Hepato-Protective Effect Of Emilia praetermissa Against Carbon Tetrachloride-Induced Hepatotoxicity In Albino Rats.

[摘要] Hepatic damage has been reported to disrupt the normal metabolism in the body and incidence ofChronic liver diseases has become an increasing burden to the society. Emilia praetermissaaqueous extractswere evaluated for their potential hepatoprotective effects against carbon tetrachloride induced hepaticdamage model. Experimental rats in different groups were subjected to different concentrations of Emiliapraetermissa leaves extract and Silymarin a standard drug for the treatment of liver disorders after carbontetrachloride induction. The hepatoprotective potentials ofEmilia praetermissa extract were accessed in theplasma and liver by the estimation of biochemical markers such as; Malondialdehde, Alkaline phosphatase,Aminotransferase, Total Bilirubin, Total Protein and Albumin. Liver histopathological examination was alsostudied. The aqueous extract of Emilia praetermissa brought about significant changes in the level of mostbiochemical parameters in a dose dependent manner. Generally, the most significant(P<0.05) protective effectwas observed at the highest dose (200mg/kg) of the extract which is more effective than the standard drug.The histopathological study also confirmed the hepatoprotective ability of the aqueous extract of Emiliapraetermissa which shows that the leaves could play a vital role in the managementliver disorders.

[学科分类] 工程和技术（综合）

[关键词] Liver disorders;Emilia praetermissa;Histopathology;Aminotransferase