Use Of Sublingual Bacterial Lysates In Stable COPD: A Case Control Study.

[摘要] Bacterial infection due to colonizers is the commonest reason for exacerbation in COPD. A vaccinationstrategy of administering antigens extracted from a lysate of the most common bacterial species involved inrespiratory exacerbation may thus reduce exacerbation rate. To evaluate the safety and efficacy of sublingualbacterial lysates in reducing COPD exacerbation and control of COPD. In this open labelled case-control study,100 patients of COPD were randomized into two different groups after being matched for severity and age. Thetreatment group received a daily sublingual dose of bacterial lysate (10 days each month for three consecutivemonths) and the control group did not. Patients were followed up with 7 visits over 1 year to evaluate COPDcontrol. Treatment group showed statistically significant reduction in decline of FEV1 and improvement in QOL,CAT score and BODE index over 1 year. There were 21 major exacerbations in control group vs. 12 in thetreatment group. Bacterial lysate had no adverse effects. Immunization with bacterial lysates showedimprovement in QOL, number of major COPD exacerbations and slowed down the disease progression.

[学科分类] 工程和技术（综合）

[关键词] COPD;Sub lingual Bacterial Lysates;CAT score;BODE index;FEV1.