Area Under Curve Method Development And Validation For The Estimation Of Nebivolol And Valsartan In Bulk And Pharmaceutical Dosage Form.

[摘要] A simple, robust, precise, UV spectroscopic method has been developed for the simultaneousestimation of Nebivolal and Valsartan in bulk and tablet dosage forms. In this paper the estimation ofthose drugs was carried out by simultaneous equation method. This method is based on measurement ofabsorption at 281nm and 251nm i.e, λ of Nebivolal and Valsartan respectively. The linearity observedmax for Nebivolal is in the range of 5-25 μg/ml and for Valsartan is in the range of 5-80 μg/ml. The accuracy ofmethods was assessed by recovery studies and was found to be within the range of 99.28%-99.26% forboth Nebivolal and Valsartan. The developed methods were validated with respect to linearity, accuracy(recovery), and precision. The method can be employed for estimation of pharmaceutical formulationswith no interference from any other excipients and diluents. The results were validated as per ICHguidelines.

[学科分类] 工程和技术（综合）

[关键词] Nebivolal;Valsartan;ICH;AUC;Validation etc.