Nephroprotective Activity of Ethanolic Extract of Musa Sapientum Fruit Peel in Gentamicin Induced Nephrotoxicity.

[摘要] To evaluate the nephroprotective activity of ethanolic extractof Musa sapientum fruit peels inGentamicin(100mg/kg, p.o. for 7 days) induced nephrotoxicity rats. Rats were treated with ethanolic extract ofMusa sapientum fruit peel (250 and 500 mg/kg,p.o) for 7 days after gentamicin. The extent of defense wasmeasured using levels of serum and urine parameters like creatinine, urea, uric acid and total protein.Additionally, oxidative stress parameters such as levels of Malonaldehyde (MDA), reduced glutathione (GSH)and activity of superoxide dismutase (SOD) and catalase (CAT) along with histopathology of kidney. Thesubstantially elevated kidney weight, urine volume, serum and urine parameters like creatinine, urea, uric acid,total protein. Oxidative stress parameters such as levels of MDA, GSH, SOD and CAT activities were found to berestored towards normalization by ethanolic extract of Musa sapientum fruit peel comparable with standarddrug Cystone. In histopathological regenerative changes were observed in kidney section of rats receivedethanolic extract of Musa sapientum fruit peel. The results suggest that the ethanolic extract of Musasapientum fruit peels possess significant nephroprotective activity.

[学科分类] 工程和技术（综合）

[关键词] Nephroprotective activity;Musa sapientum;Gentamicin induced nephrotoxicity etc.