Characteristics of Acanthus ilicifolius Leaves as Raw Materials for Drugs and Cosmetics.

[摘要] Acanthus ilicifolius is a true mangrove which is known to have antibacterial, anti-inflammatory, antioxidant andanticancer properties. These properties highly support A. ilicifolius to be developed as a raw material formedicine and cosmetics. The objective of this study is to investigate the characteristics of antioxidants,antibacterial and toxicity of A. ilicifolius leaves as raw materials for medicine and cosmetics using extractionfrom leaves of A. ilicifolius. We used three solvent, namely ethanol, methanol and chloroform, to know whichsolvent would give the highest yield. Ethanol gave the the highest yield of extraction, as much as 42.07%. Then,the phytochemical content, the antioxidant activity, the antibacterial activity against Propionibacterium acne,and the toxicity of the ethanolic extract of A. ilicifolius leaves was analyzed. The results showed thephytochemical compounds found in the extract was flavonoids, tannins, saponins and steroids. Testing ofantioxidant activity using DPPH showed IC50 values of 12.38 ppm and toxicity with values of LC50 179.59 ppm.The results of antimicrobial activity against P. acne by disk diffusion method showed the highest results at aconcentration of extract 5% with inhibition zones of 7.26 mm. From the test results above, it is indicated thatthe ethanolic extract of A. ilicifolius leaves has high antioxidant activity and high toxicity, so it is potential to bean anticancer drug or an anti-aging cosmetic. Its antibacterial activity was also able to inhibit P. acne bacteria,thus it was approved to be a raw material of acne-treating product.

[学科分类] 工程和技术（综合）

[关键词] Acanthus ilicifolius;Propionibacterium acne;Antioxidant;Phytochemical Content;Toxicity