High Sensitivity C - Reactive Protein Prognostic Role In Patients With Acute Myocardial Infarction.

[摘要] Acute Myocardial Infarction (AMI), also known as a heart attack, is a medical emergency that is the leadingcause of death for men and women worldwide. Acute coronary syndromes include unstable angina and acutemyocardial infarction, both of which are caused by myocardial ischemia and or necrosis, which causes inflammationand subsequent repair processes. Chronic inflammatory responses and oxidative stress play a mysterious role in theinitiation and progression of acute coronary syndromes (ACS). Acute myocardial infarction is a seriouscardiovascular event that is associated with significant morbidity and mortality. This study aims to study the levels ofserum highly sensitive C-reactive protein in patients with AMI as compared to the control. The major purpose of thisstudy is to assess serum high sensitive C-reactive protein levels in AMI patients and to connect serum high sensitiveC-reactive protein levels with AMI-related mortality. The secondary purpose is to predict AMI early diagnosis,improved management and therapy, and prognosis. The present study was carried out in the Department ofBiochemistry and Central Investigation Laboratory in collaboration with the Department of Medicine, Intense cardiaccare units, medical intensive care units, and emergency and private hospitals. The study was approved byInstitutional Ethical and Research Committee to use human subjects in the research study. Informed consent wastaken from patient and control subjects. Out of 100 subjects, 50 were acute myocardial infarction patients and 50were age matched healthy controls.The study was conducted from January 2020 to December 2021. The Microlab300 analyzers (semi‑autoanalyzer) were used to assess highly Sensitive C - reactive protein concentrations, and thecomparisons between the two groups were examined using an unpaired t‑test. A P < 0.05 was deemed statisticallyrd significant. There was a substantial elevated in the mean serum highly sensitive C-reactive protein in cases on 0, 3th and 7 day were 7.0±2.92 mg/dl, 5.95±2.32 mg/dl, 3.46±2.70 mg/dl day respectively which were higher thancontrols group (2.45±1.34 mg/dl). Comparison between control and serum highly sensitive C-reactive protein on 0rd th and 3 day was found to be more significant than that of 7 day. Unpaired t-test showed that there was significantincrease in serum highly sensitive C-reactive protein level in cases as compared to controls (p<0.005). As a result, thestudy concludes that serum high sensitivity C-reactive protein levels play an important role in the diagnosis andtreatment of AMI.

[学科分类] 工程和技术（综合）

[关键词] Acute Myocardial Infarction;High Sensitive C - reactive protein;Acute Coronary Syndromes and Mortality.