Physiology Of Calcitriol, Its Role In Body Functions And Highlights About Immunological And Thyroid Activities: A Molecular View On Vitamin D Receptors And Gene Polymorphism.

[摘要] Vitamin D is a secosteroid hormone, which is attracting the attention of the scientists for itstherapeutic functions. As it is playing the pleotropic role in multiple physiological process, the deficiencyof vitamin D is considered as the major health issue. The main reason for the deficiency of vitamin D is lackof exposure to the sunlight. The vitamin D receptor is a member of steroid hormone super family. Recentlythe highlighting issues are the action of vitamin D in non-skeletal tissues, cardiovascular, diabetes mellitus,cancer. currently, there is a need to increase the vitamin D status in individuals worldwide as it has beenshown to improve the auto immune and infectious disease, type-2 diabetes mellitus, neurocognitivedisorders. This review is elucidating the central role of vitamin D in maintaining the overall health.Highlights about vitamin D receptors and a molecular view on vitamin D receptor gene polymorphism.

[学科分类] 工程和技术（综合）

[关键词] Vitamin D;steroid hormone;gene polymorphism.