Estimation and Correlation of Salivary Sialic acid level between OSCC and PMD.

[摘要] Oral cancer is a major threat to public health. It has a high mortality rate and it is the sixthcommon cancer in humans in the world [1]. About 50-70% of cancer related deaths in India are due tooral cancers. India has the highest incidence of Oral Squamous Cell Carcinoma (OSCC) in the world. Oralcancer is usually preceded by oral precancerous lesions & conditions (now named as potentiallymalignant disorders (PMD)) such as oral leukoplakia, OSMF with a malignant transformation rate from0.6 to 3.6%. The present clinical ways to deal with cancer diagnosis and treatment involves invasive &painful procedures Therefore, a noninvasive procedure using a tumor marker is essential for earlydiagnosis of oral cancer as well as to monitor its progression during treatment. Tumor markers arebiochemical substances elaborated by tumor cells into the circulation. Once such substance is Sialic acid(N-Acetylneuraminic acid) level which was analyzed in the saliva and it is to be the first choice ofscreening and identification of potential biomarkers in the oral cancer [2]. So, this present study is toevaluate and correlate the levels of Salivary Sialic acid in patients with OSCC and oral premalignancy withthose of healthy controls.

[学科分类] 工程和技术（综合）

[关键词] PMD;OSCC;Sialic acid.