Oxidative Stress Status Indicated By Serum MDA Levels And Lipid Profile In Obese And Non Obese Women With PCOS.

[摘要] Polycystic Ovary Syndrome (PCOS) is a multifactorial reproductive healthcare problem affecting4-12% of women and a leading cause of female infertility worldwide. Over the past decade emergingevidence has shown that Oxidative Stress (OS) indicated by increased MDA (Malondialdehyde) levels,decreased antioxidant status and dyslipidemia are often linked with PCOS. Our study determines lipidprofile and OS indicated by MDA were measured in serum of obese and non obese PCOS subjects and agematched controls in women from South India. Case-control study was carried out at the BiochemistryDepartment, Koppal Institute of Medical Sciences, Koppal, India from July 2015 to March 2018. It included100 women with PCOS (50- obese and 50 normal) and 100 control subjects (50- obese and 50 normal),aged 18 to 40 years. Fasting lipid profile (cholesterol, high density lipoprotein cholesterol (HDL) andtriglycerides) were determined using enzymatic method. Very low density lipoprotein cholesterol (VLDL)value was estimated using the Friedwald formula. Malonaldehyde (MDA) were determined asThiobarbituric acid reactive substances (TBARS). LDL, VLDL and HDL showed statistical significancebetween all the groups. However, LDL and VLDL were increased compared to controls and HDL wasdecreased. In triglyceride all the groups showed statistical significance except between control normaland PCOS normal. In Total cholesterol there was showed statistical significance except between PCOSnormal and PCOS obese and control obese and PCOS obese. MDA levels were increased in women withPCOS irrespective of BMI compared to their respective controls with a p value of <0.001, suggesting asignificant inverse correlation between PON1 activity and MDA concentrations in women with PCOSirrespective of BMI.Our results revealed that PCOS is associated with dyslipidemia and increasedoxidative status indicated by serum MDA levels.

[学科分类] 工程和技术（综合）

[关键词] Polycystic ovarian syndrome;Lipid profile and MDA