Swietenia macrophylla King Wood Residues: A Source of Cycloartane Triterpenoids.

[摘要] Cycloartanes are tetracyclic triterpenoids that contain the cyclopropane ring at C-9 and C-10. Theywidely occur in plants and are renowned for their pharmacological properties. In the Meliaceae family,these triterpenoids have been found in some genera; however, they have been rarely reported in Swietenia.In the present work, we identified for the first time cycloartane triterpenes in wood residues of Swieteniamacrophylla (mahogany) and evaluated their activity against fungi of medical interest. Samples ofmahogany from windows with more than 30 years of use were donated to this study and then subjected toextractions with hexane followed by methanol. The hexane extract was subjected to chromatographicprocedures for purification of cycloeucalenol and ß-sitosterol esterified (mixture), cycloeucalenone andcycloeucalenol. Chromatographic fractionation of fraction 1 of the methanolic extract led to the purificationof cycloeucalenol, cycloart-23E-en-3β,25-diol and a mixture of 24-metileno-cicloartan-3β-ol andcycloartenol.In the antifungal assay, the most active compounds were a mixture of cycloeucalenol and ß- sitosterol with a MIC of 80 µg/mL for Candida albicans and Cryptococcus gattii; cycloeucalenol with a MICof 80 µg/mL for C. gattii. This study was an opportunity to add to the knowledge on the secondarymetabolites of wood of this species as well as search for active principles.

[学科分类] 工程和技术（综合）

[关键词] Mahogany;Meliaceae;NMR;antifungal