Hepato-toxic Effects of Pyrethroid Pesticides on Adult Mice: Exploring Potential Health Implications.

[摘要] Pyrethroids are synthetic chemical compounds derived from the naturally occurring pyrethrinsfound in chrysanthemum flowers. They are effectively used in agricultural and residential settings tocontrol various pests.In this study, the potential toxic effects of cypermethrin on the liver of albino miceare investigated with a multidisciplinary approach by using physiological, biochemical, andhistopathological parameters. 126 Adult swiss albino mice weighing 20- 25 grams are used after approvalof the institutional ethical committee. In the present study low doses of cypermethrin are given to micethrough the oral route. Cymbush 25 EC is used which contains 25% EC cypermethrin. The recommendeddose of it is 3-5ml for foliage spraying. On the day of sacrifice, blood is withdrawn from the retro-orbitalsinus of mice by using a capillary tube. Biochemical parameters demonstrated the rise in plasma levels ofAST and ALT of treated mice according to the dose and duration of the drug given. On histologicalobservation of the liver of treated mice, pathological changes are seen. Marked necrosis of hepatocytes isobserved in different groups of treated mice.

[学科分类] 工程和技术（综合）

[关键词] Pyrethroid pesticide;Cypermethrin;Liver toxicity;Hepatocytes;Necrosis.