An Analysis Of Adverse Drug Reactions In Special Age Groups - Geriatrics And Paediatrics At Tertiary Care Teaching Hospital.

[摘要] Geriatrics and paediatrics are two extremes age groups and elderly people commonlyexperiences adverse drug reaction since they exhibit numerous risk factors.. Most of the time ADRsoccurring in elderly people goes unnoticed because it is difficult to recognise as they often present withunspecific symptoms. So more attention should be paid to identify ADRs in elderly people. Hencepharmacovigillance plays a crucial role in ADR monitoring. To assess and analyse the clinical spectrum ofadverse drug reaction in geriatric and paediatric age group. 1. To assess the pattern of Adverse DrugReactions in geriatric and paediatric age group. 2. To assess the drugs commonly involved in thedevelopment of ADRs in geriatric and paediatric age group. 3. To assess the relationship between ADRand causative drug by causality assessment. All ADRs reported in geriatric age group(≥ 65 years) andpaediatric age group(≤ 12 years) indoor as well outdoor patients from January, 2017 to June, 2017 at ADRmonitoring centre, Department of Pharmacology, AVBRH hospital , sawangi( meghe) , wardha wereidentified. ADRs reported by hospital staff including nurses, physicians and also spontaneously reportedADRs were collected and tabulated in CDSCO form.And ADR data has been generated. A retrospectiveanalysis was done to find out the commonly involved drugs and clinical presentation of the geriatric andpaediatric age group of patients. Causality assessment was done by using WHO causality assessmentscale. A total of 56 ADRs were collected, tabulated in CDSCO forms, analyzed and assessed on WHOcausality assessment scale. Out of 56 ADRs 37 were from geriatric patients (66.08%) while 19 frompaediatric patients (33.93%).The most common causal drugs in geriatric patients was cardiovascular(14, 37.84%) followed by antimicrobials (7, 10.91%). While in paediatric patients, the most commoncausal drug group was antimicrobials (18, 94.74%) while only one ADR was reported with bloodproducts (1, 5.26%). Causality assessment for majority of ADRs in geriatrics and paediatrics was probable(30, 53.58%) and possible (24, 42.85%) Extremes of age, associated co morbidity and polypharmacyincreases the risk of ADRs in elderly. This calls for the need for active surveillance of drug safetymonitoring in these ADR prone populations. Here pharmacovigillance plays crucial role in monitoringADRs.

[学科分类] 工程和技术（综合）

[关键词] ADR- Adverse drug reaction;WHO-UMC scale.