Synthesis of Novel Heterocyclic Fused Systems as Potential Leads – Oxazino [5,6-b], Pyrazino [ 5,6-b] and Imidazolo [4,5-b]- Quinoxalines.

[摘要] Heterocyclic systems such as piperazines and pyrazines have been known to exhibit a wide rangeof biological activity. Fused systems incorporating these two heterocyclic moieties have shown enhancedactivity in having a rigid conformation. In an attempt to further ‘freeze’ the conformation, extended fusionwith bidentate nucleophiles has been explored in this paper giving rise to oxazino[5,6-b], pyrazino[5,6-b]and imidazole[4,5-b] quinoxalines. Such transformations have been brought about by the cyclo- condensation of the quinoxaline ring with aliphatic bidentate nucleophiles as possible pharmacophores.These novel molecules which have been synthesized holds significance in being probable potential leads astwo pharmacophoric moieties are embedded in their system – the heterocyclic ring and the aliphaticbidentate nucleophile.

[学科分类] 工程和技术（综合）

[关键词] Quinoxalines;Bidentate nucleophile;Oxazino [5;6-b] quinoxaline;Pyrazino [5;6-b] quinoxaline;Imidazole[4;5-b] quinoxaline;Pharmacophore