Genotype Analysis of MLH1 (-93G/A) Polymorphism In Alcohol And Tobacco Consumers Associated With Risk Of Head And Neck Squamous Cell Carcinoma (HNSCC).

[摘要] Head and Neck cancer is a devastating disease and is the sixth most prevalent cancer accountingfor 3% of all cancer. Majority of head and neck cancer originated from mucosal lining of the upper aero- digestive tract part especially in larynx, pharynx, oral cavity and nasal cavity collectively termed head andneck squamous cell carcinoma. Tobacco and alcohol are crucial risk factors of head and neck cancer.Additional etiologies that cause head and neck cancer are viral infection and genetic susceptibility factorsand its association with head and neck cancer is still to be understood. Genetic instability is one of theprevalent features of all types of cancers. Genetic blueprint (DNA) is usually damaged by exogenous,endogenous mutant agents and genetic variant in combination with environmental exposure toexogenous/endogenous carcinogens is the main factor responsible for differences between individuals.Single nucleotide polymorphisms in DDR (DNA damage repair) genes are accountable for multiplecancers including head and neck cancer. MLH1 DNA repair gene plays an important role in BER pathway.DNA repair gene single nucleotide polymorphism (SNPs) can lead to changes in individual accountabilityto larynx cancer. In this time line article, we focus on the correlation between polymorphisms in thegenomic stability pathway and emergence of head and neck cancer.

[学科分类] 工程和技术（综合）

[关键词] SNP (Single Nucleotide polymorphism);DNA repair;MLH1 (MutL homolog 1)