Investigation of Lipid Polymer Hybrid Nanocarriers for Oral Felodipine Delivery: Formulation, Method, In-vitro and Ex-vivo Evaluation

[摘要] The antihypertensive felodipine is a calcium-channel blocking agent. It is practically insoluble in waterand shows low oral bioavailability (15%-20%). This investigation aims to formulate and characterize felodipinelipid polymer hybrid nanocarriers (LPHNs) to be given orally by two nanovesicles formulating methods and makecomparative analysis through characterization process and in vitro and ex vivo intestinal permeation evaluation.The felodipine LPHNs formulations (HF1-HF3) were prepared by the new microwave-based method and thatfelodipine LPHNs formulations (HF4-HF6) were prepared by a single emulsification solvent evaporation technique(SESET). All formulations (HF1-HF6) enter the characterization process. The felodipine LPHNs formulations(HF1-HF6) were prepared successfully and undergo different characterization processes to make a comparativestudy between formulations prepared by different methods. It was found that formulas prepare by a microwavebased method are most superior to the SESET. The felodipine LPHNs formulations HF1-HF3 has lower particlesize, lower PDI and higher zeta potential, significantly higher (p< 0.05) dissolution rate, and significantly higher(p< 0.05) intestinal permeation study than the felodipine LPHNs formulations HF4-HF6. The microwave-basedmethod is a very successful technique in preparing felodipine LPHNs formulations (HF1-HF3) and prepotent tothe SESET. All the felodipine LPHNs formulations (HF1-HF6) show extended drug release nanosystem.

[学科分类] 计算机网络和通讯

[关键词] Lipid-polymer hybrid nanocarriers;Felodipine;Microwave based method;SESET.;Lipid-polymer hybrid nanocarriers;Felodipine;Microwave based method;SESET