17T223A, a new spiroximicin family compound from Streptomyces sp.

[摘要] In this study, we successfully isolated two compounds, 17T223A (1, C22H22O10) and 17T223B(2, C22H20O9), from a culture of Streptomyces sp.17T223. Spectroscopic analyses revealed that thesetwo compounds belong to the spiroximicin family.The chemical structure of 2 was consistent with thatof the established antibiotic spiroximicin, whereas1 was previously unknown. Furthermore, 1 exhibited moderate radical-scavenging activity, with anED50 of 1000 μM, whereas 2 showed no radical-scavenging activity, even at an ED50 of 2000 μM. Significant antimicrobial activity was exhibited by 2whereas 1 exhibited no antimicrobial activity, suggesting that the epoxide portion of 2 influences itsantimicrobial activity.

[学科分类] 微生物学和免疫学

[关键词] antimicrobial activity;2;2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger;spiroximicin;nuclear magnetic resonance (NMR);Streptomyces sp.