Diagnosis of lymph node metastasis in head and neck squamous cell carcinoma using deep learning

[摘要] Background To build an automatic pathological diagnosis model to assess the lymph node metastasis status of head and neck squamous cell carcinoma (HNSCC) based on deep learning algorithms. Study Design A retrospective study. Methods A diagnostic model integrating two-step deep learning networks was trained to analyze the metastasis status in 85 images of HNSCC lymph nodes. The diagnostic model was tested in a test set of 21 images with metastasis and 29 images without metastasis. All images were scanned from HNSCC lymph node sections stained with hematoxylin–eosin (HE). Results In the test set, the overall accuracy, sensitivity, and specificity of the diagnostic model reached 86%, 100%, and 75.9%, respectively. Conclusions Our two-step diagnostic model can be used to automatically assess the status of HNSCC lymph node metastasis with high sensitivity. Level of evidence NA.

[学科分类] 环境科学（综合）

[关键词] convolutional neural network;deep learning;digital pathology;head and neck squamous cell carcinoma;lymph node metastasis