Neutrophil and lymphocyte ratio in craniocervicalartery dissection and prognostic correlations of theblood biomarkers

[摘要] Background & Objective: The aim of this study was to investigate the relationship of neutrophil tolymphocyte ratio (NLR) and other blood cells markers in craniocervical artery dissection patients andthe dynamic changes of these biomarkers during the disease course, and effects on prognosis of thepatients. Method: Cranial MR imaging, cranial and cervical MR angiography and DSA were examined,and diffusion weighted imaging (DWI) was performed to show the acute lesion(s). Results: Forty-sixpatients with craniocervical artery dissection were included in this study; they had a mean age of42 years. Almost 60% of the patients (n=27) were admitted during acute state. Almost 2/3 of caseshad extracranial dissection (n=31) and nearly 40% of the patients (n=18) had trauma. Neutrophil tolymphocyte ratio (NLR) was observed to be higher in the acute phase of the disease while the ratiodecreased in the chronic phase. Low hemoglobin, high lymphocyte and a high NLR were found tohave a negative correlation with the National Institutes of Health Stroke Scale (NIHSS).Conclusion: Elevation of neutrophil was higher in acute craniocervical artery dissection as a marker ofacute inflammatory response. High NLR, low hemoglobin and high eosinophil levels were associatedwith worse prognosis and functional outcomes.

[学科分类] 精神健康和精神病学

[关键词] Craniocervical artery dissection;neutrophil to lymphocyte ratio (NLR);prognosis.