Myo-inositol in geriatric patients with cognitiveimpairment

[摘要] Background & Objective: Cognitive impairment, in geriatric population, is reported in patients withdepression, mild cognitive impairment (MCI), and dementia. MCI is the transitional stage beforedementia, with annual conversion rate to dementia of about 20%. Early diagnosis of the underlyingcause of cognitive impairment in geriatric patients is crucial for proper management. This could beachieved through proton magnetic resonance spectroscopy. We aimed to study the difference of frontal,posterior cingulate gyrus, and occipital myo-inositol (MI), and myo-inositol/creatine (MI/Cr) ratiobetween patients with MCI, and cognitive impairment associated with geriatric depression; and study ifthese metabolites could differentiate between MCI and cognitive impairment associated with geriatricdepression. Methods: Geriatric patients with MCI, and elderly patients with depression associatedwith cognitive impairment, along with sex and age matched healthy control were evaluated clinicallyand underwent neuropsychological testing, laboratory tests as well as brain MRI and proton magneticresonance spectroscopy at baseline. Patients were reevaluated clinically, and neuropsychologically at12, and 24 months from baseline. Results: The present study included 62 subjects. Patients with MCIhad significantly higher posterior cingulate gyrus, occipital MI/Cr ratio, and frontal MI and MI/Cr ratiothan normal controls. No differences were seen between geriatric patients with cognitive impairmentassociated with depression and those with MCI and healthy control in any of the studied metabolitesin the studied brain regions.Conclusion: Elevated posterior cingulate gyrus, occipital, and frontal MI/Cr ratio, and frontal MI levelcould help to identify patients with MCI from healthy control, but could not differentiate betweenMCI and cognitive impairment associated with depression.

[学科分类] 精神健康和精神病学

[关键词] Mild cognitive impairment;geriatric depression;myo-inositol;magnetic resonancespectroscopy.