Quality of life and activities of daily living of myastheniagravis patients in Hospital Seberang Jaya, Malaysiausing MGQOL-15 and MGADL scores: A cross sectionalstudy

[摘要] Background & Objective: Myasthenia gravis (MG) is an immune mediated neuromuscular diseasewith a wide range of clinical symptoms causing fatigability, which can influence quality of life (QoL)and activity of daily living (ADL). Patient-derived quality of life, as assessed by questionnaires hasproven to be an essential outcome measures when used in conjunction with clinical examination. Theobjective of this study is to explore factors associated with QoL and ADL of MG patients in HospitalSeberang Jaya, Malaysia. Methods: In this cross-sectional study 35 MG patients were recruited fromthe Neurology clinic of Hospital Seberang Jaya, Penang. An interview-administered questionnaire wasutilized. The questionnaire consisted of 3 parts: Socio-demographics (age, gender, ethnicity), Clinicalfactors (MG type, MG crisis, Ach Antibody positivity, thymoma was recorded) and QoL assessmentusing validated MG-QoL-15 and MGADL questionnaires respectively. Descriptive and bivariateanalysis was conducted using SPSS version 23. Results: Our sample were 57% males, and the meanage was 54.34 years, range 19 to 81 years. Higher score of MG-QoL-15 and MGADL indicates lowerQoL of MG patients. In bivariate analysis, Non-Malays were 8 times more likely to have better QoLcompared to Malays (OR=8, 95%CI =1.726-37.09, p = 0.005). Patients with poorer ADL score were6.5 times more likely to have lower QOL compared to those with lower ADL score (OR = 6.5, 95%CI = 1.3-31.8, p = 0.016). Other clinical factors were not significantly associated with QoL.Conclusion: This study showed that the non-Malay MG patients and those with lower grades of thedisease (grade I to II) had better QoL.

[学科分类] 精神健康和精神病学

[关键词] Myasthenia gravis;quality of life;myasthenia gravis-quality of life 15;myasthenia gravisactivities of daily living;validation in Malay