Evaluation of iris epithelial and stromal thickness inpatients with migraine by using optical coherencetomography

[摘要] Objective: The amount of light reaching to the retina is an important factor for photophobia formation.Therefore, investigation of iris thickness in patients with migraine can be valuable for revealing theirsusceptibility to photophobia. In this study, it was aimed to evaluate the iris epithelial and stromalthickness, retinal ganglion cell layer (RGCL) thickness, and retinal nerve fibre layer (RNFL) thicknessof patients with migraine. Methods: Forty-nine migraine patients (Group 1) and 50 control participants(Group 2) were included into this study. For obtaining standard measure in all participants, the epithelialand stromal thickness of dilatory and sphincter iris muscle was measured from the equal distance tothe pupillary margin by using anterior segment mode of optical coherence tomography (AS-OCT).Additionally, RNFL and RGCL thicknesses were measured by using posterior segment mode of OCT(PS-OCT). Results: The epithelial thickness of iris sphincter muscle and the epithelial thickness of irisdilatory muscle was found to be significantly higher in patients with migraine compared to controlsubjects (p<0.001, p=0.001 respectively). Additionally the stromal thickness of both iris sphincter andiris dilatory muscle (p<0.001, p<0.001 respectively) as well as the total thickness of iris sphincter andiris dilatory muscle was significantly higher in patients with migraine than control subjects (p<0.001,p=0.02 respectively). However, no significant difference was found between patients with migraineand control subjects in terms of RNFL and RGCL thicknesses (p=0.1 and p=0.7 respectively).Conclusion: The finding of high epithelial and stromal iris thickness in patients with migraine maysupport the possible role of increased pupillary dynamic in photophobia formation.

[学科分类] 精神健康和精神病学

[关键词] Migraine;choroid thickness;retinal nerve fibre layers